Do not accept the conventional wisdom. Do not accept the idea that something can’t be accomplished because the scientific literature says it can’t. Trust your instincts. Allow yourself a wide latitude in your speculations. Don’t depend on the literature. It could be right or it could be completely wrong. Spread all your hunches out before you, and go with the ones that you think are the most probable. Select the one that you can test easily and quickly. Don’t assume that it has to be overly complicated to be of value, since the simplest experiments yield the most unequivocal result. Just do the experiment!